The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2

Lakhani, Sunil R., Gusterson, Barry A., Jacquemier, Jocelyne, Sloane, John P., Anderson, Thomas J., van de Vijver, Marc J., Venter, Deon, Freeman, Alex, Antoniou, Antonios, McGuffog, Lesley, Smyth, Elizabeth, Steel, C. Michael, Haites, Nava, Scott, Rodney J., Goldgar, David, Neuhausen, Susan, Daly, Peter A., Ormiston, Wilma, McManus, Ross, Scherneck, Siegfried, Ponder, Bruce A. J., Futreal, P. Andrew, Peto, Julian, Stoppa-Lyonnet, Dominique, Bignon, Yves-Jean, Struewing, Jeffery P., Bishop, D. Timothy, Klijn, J.G.M., Devilee, Peter, Cornelisse, Cees J., Lasset, Christine, Lenoir, Gilbert, Barkardottir, Rosa Bjork, Egilsson, Valgardur, Hamann, Ute, Chang-Claude, Jenny, Sobol, Hagay, Weber, Barbara, Easton, Douglas F. and Stratton, Michael R. (2000) The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2. Clinical Cancer Research, 6 3: 782-789.

Author Lakhani, Sunil R.
Gusterson, Barry A.
Jacquemier, Jocelyne
Sloane, John P.
Anderson, Thomas J.
van de Vijver, Marc J.
Venter, Deon
Freeman, Alex
Antoniou, Antonios
McGuffog, Lesley
Smyth, Elizabeth
Steel, C. Michael
Haites, Nava
Scott, Rodney J.
Goldgar, David
Neuhausen, Susan
Daly, Peter A.
Ormiston, Wilma
McManus, Ross
Scherneck, Siegfried
Ponder, Bruce A. J.
Futreal, P. Andrew
Peto, Julian
Stoppa-Lyonnet, Dominique
Bignon, Yves-Jean
Struewing, Jeffery P.
Bishop, D. Timothy
Klijn, J.G.M.
Devilee, Peter
Cornelisse, Cees J.
Lasset, Christine
Lenoir, Gilbert
Barkardottir, Rosa Bjork
Egilsson, Valgardur
Hamann, Ute
Chang-Claude, Jenny
Sobol, Hagay
Weber, Barbara
Easton, Douglas F.
Stratton, Michael R.
Title The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2
Journal name Clinical Cancer Research   Check publisher's open access policy
ISSN 1078-0432
Publication date 2000-03
Sub-type Article (original research)
Volume 6
Issue 3
Start page 782
End page 789
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Language eng
Abstract Breast cancers arising in carriers of mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, differ histologically from each other and from breast cancers unselected for a family history. However, a substantial proportion of families with multiple cases of breast cancer is not attributable to these two genes (non-BRCA1/2 families). We have now characterized the pathology of 82 breast cancers from non-BRCA1/2 families. Breast cancers in non-BRCA1/2 families were of lower grade (P = 0.0018), showed fewer mitoses (P < 0.0001), less nuclear pleomorphism (P = 0.0014), less lymphocytic infiltrate (P < 0.0001), a lesser extent of the tumor with a continuous pushing margin (P = 0.004), a lesser extent of the tumor composed of solid sheets of cells (P = 0.0047), less necrosis (P = 0.002), and were more likely to be of invasive lobular type (P = 0.0003) than breast cancers arising in BRCA1 mutation carriers. In comparison with BRCA2 tumors, non- BRCA1/2 tumors were lower grade (P = 0.017) and exhibited less pleomorphism (P = 0.01) and more tubule formation (P = 0.05). In comparison with control breast cancers unselected for a family history of the disease, non-BRCA1/2 tumors were of significantly lower grade (P = 0.001), showed less pleomorphism (P = 0.0002), and had a lower mitotic count (P = 0.003). The results indicate that non-BRCA1/2 breast cancers differ histologically from both BRCA1 and BRCA2 breast cancers and are overall of lower grade. They also suggest that non-BRCA1/2 breast cancers differ from nonfamilial breast cancers, but these differences may be attributable to various types of bias.
Keyword Germline mutations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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