Putting the brakes on cylindromatosis?

Lakhani, Sunil R. (2004) Putting the brakes on cylindromatosis?. New England Journal of Medicine, 350 2: 187-188. doi:10.1056/NEJMcibr032650


Author Lakhani, Sunil R.
Title Putting the brakes on cylindromatosis?
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793
1533-4406
Publication date 2004-01-08
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1056/NEJMcibr032650
Open Access Status
Volume 350
Issue 2
Start page 187
End page 188
Total pages 2
Place of publication Boston, MA, United States
Publisher Massachusetts Medical Society
Language eng
Abstract A man cannot become a competent surgeon without the full knowledge of human anatomy and physiology, and the physician without physiology and chemistry flounders along in an aimless fashion, never able to gain any accurate conception of disease, practicing a sort of popgun pharmacy, hitting now the malady and again the patient, he himself not knowing which. — Sir William Osler (1849–1919) In patients with familial cylindromatosis, or "turban tumors," numerous benign skin adnexal tumors develop, principally on the head and neck (Figure 1). This rare disorder is caused by a mutation of the CYLD gene and hasgene and has a variable penetrance. Thanks to three recent studies 2-4 and, in particular, to the work of Brummelkamp and colleagues, 2 we now have a more accurate conception of the disease process and thus a hope of developing a mechanism-driven therapy.
Keyword Nf-Kappa-B
Cyld
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Medicine Publications
 
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