Ceftizoxime was used to treat 20 infants with suspected bacterial infections. The dosages of ceftizoxime ranged from 140 mg to 300 mg/kg/day with a mean of 232 mg/kg/day. The duration of therapy ranged from 1 to 12 days with a mean of 4.5 days. Satisfactory clinical response was seen in 86% (13/15) of the evaluated cases. Five cases could not be evaluated. Bacteria were recovered from nine infants and included: group B streptococcus (4), Staphylococcus aureus (2), Streptococcus faecalis (1), Flavobacterium meningosepticwn (1) and Serratia marcescens (1). A generalized erythematous maculpapular rash occurred in one infant receiving ceftizoxime. Two other infants had transient mild hyperbilirubinaemia which resolved without discontinuing the antibiotic. Ceftizoxime may be an acceptable antibiotic for treating suspected neonatal infections.