Histocompatibility determinants in childhood postinfectious encephalomyelitis

Woody, Robert C., Steele, Russell W., Charlton, Ronald K. and Smith, Valaria (1989) Histocompatibility determinants in childhood postinfectious encephalomyelitis. Journal of Child Neurology, 4 3: 204-207. doi:10.1177/088307388900400311


Author Woody, Robert C.
Steele, Russell W.
Charlton, Ronald K.
Smith, Valaria
Title Histocompatibility determinants in childhood postinfectious encephalomyelitis
Journal name Journal of Child Neurology   Check publisher's open access policy
ISSN 0883-0738
1708-8283
Publication date 1989-07
Sub-type Article (original research)
DOI 10.1177/088307388900400311
Volume 4
Issue 3
Start page 204
End page 207
Total pages 4
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Abstract Postinfectious encephalomyelitis and multiple sclerosis have clinical, immunologic, and neuroradiographic similarities. We studied HLA determinants in six white children consecutively diagnosed with postinfectious encephalomyelitis. Each of the children had HLA determinants which have been associated with multiple sclerosis. Relative risk (RR) calculations demonstrated that these antigens and genotypes occurred significantly more often in patients with postinfectious encephalomyelitis than in the control population (A3, RR 6.14; B7, RR 6.14; DR2, RR 4.51; A3B7, RR 9.36; A3DR2, RR 5.83; B7DR2, RR 6.13; A3B7DR2, RR 10.90). These data suggest that children with postinfectious encephalomyelitis are genetically predisposed to this demyelinating disease. Although the same HLA determinants were found in these patients as in those with multiple sclerosis, studies of a larger number of postinfectious encephalomyelitis patients will be needed before it can be concluded that the two diseases share a common genetic propensity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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