Effects of adenine arabinoside on cellular immune mechanisms in humans

Steele, Russell W., Chapa, Isidoro A., Vincent, Monroe M., Hensen, Sally A. and Keeney, Ronald E. (1975) Effects of adenine arabinoside on cellular immune mechanisms in humans. Antimicrobial Agents and Chemotherapy, 7 2: 203-207.

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Author Steele, Russell W.
Chapa, Isidoro A.
Vincent, Monroe M.
Hensen, Sally A.
Keeney, Ronald E.
Title Effects of adenine arabinoside on cellular immune mechanisms in humans
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 1975
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 7
Issue 2
Start page 203
End page 207
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract In vitro lymphocyte blastogenic responses to the commonly employed mitogens, phytohemagglutinin, pokeweed, and concanavalin A, were evaluated when adenine arabinoside (ara-A) in a concentration of 3 μg/ml was added to the culture materials. Similarly, blastogenic and cytotoxic responses to cell cultures persistently infected with herpes simplex virus 1, herpes simplex virus 2, and varicella-zoster virus were determined in the presence of ara-A. No depression of these cellular immune responses by ara-A was demonstrated. This was in contrast to the effect of cytosine arabinoside, which at a concentration of 3 μg/ml severely inhibited these immune responses. Further studies examined lymphocyte blastogenic responses to the mitogens and blastogenic and cytotoxic responses specific for the herpes group virus infecting patients who were subsequently treated with ara-A; determinations were made before, during, and after treatment. In vitro responses during and after treatment with ara-A were unchanged or often enhanced as compared to pretreatment values. Therefore, the antiviral chemotherapeutic agent, ara-A, does not appear to depress the host's cellular immune responses, which are vital to successful elimination of invading herpes group viruses.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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