Skin test and blastogenic responses to Sporotrichun schenckii

Steele, R. W., Cannady, P. B., Moore, W. L. and Gentry, L. O. (1976) Skin test and blastogenic responses to Sporotrichun schenckii. Journal of Clinical Investigation, 57 1: 156-160. doi:10.1172/JCI108255

Author Steele, R. W.
Cannady, P. B.
Moore, W. L.
Gentry, L. O.
Title Skin test and blastogenic responses to Sporotrichun schenckii
Journal name Journal of Clinical Investigation   Check publisher's open access policy
ISSN 0021-9738
Publication date 1976-01
Sub-type Article (original research)
DOI 10.1172/JCI108255
Volume 57
Issue 1
Start page 156
End page 160
Total pages 5
Place of publication Ann Arbor, MI, United States
Publisher American Society for Clinical Investigation
Language eng
Abstract In vivo skin testing and in vitro lymphocyte blastogenesis were evaluated in a young adult population as methods for detecting cellular immunity to Sporotrichum schenckii. Similar procedures for Candida albicans and Coccidioides immitis were also investigated. 5 of 143 subjects had positive skin tests and 14 had positive blastogenic responses to S. schenckii. These 14 subjects also exhibited unusually high responses to C. albicans in vitro and 11 of the 14 were female. Data demonstrated a correlation coefficient of 0.89 when comparing the blastogenic assays for S. schenckii and C. albicans, suggesting cross antigenicity. Intact cellular immune mechanisms in combination with exposure to C. albicans may protect the host from systemic infection with S. schenckii. Although a limited number of subjects were studied, as a group, females had more vigorous cellular immune responses to C. albicans than males. The rare occurence of sporothrix infection in females as compared to males may be the result of antigenic stimulation from commonly observed vaginal colonization with C. albicans. The present data indirectly support this hypothesis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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