Pharmacokinetics of ceftriaxone in pediatric patients with meningitis

Steele, Russell W., Eyre, Linda B., Bradsher, Robert W., Weinfeld, Robert E., Patel, Indravadan H. and Spicehandler, Jonathan (1983) Pharmacokinetics of ceftriaxone in pediatric patients with meningitis. Antimicrobial Agents and Chemotherapy, 23 2: 191-194.

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Author Steele, Russell W.
Eyre, Linda B.
Bradsher, Robert W.
Weinfeld, Robert E.
Patel, Indravadan H.
Spicehandler, Jonathan
Title Pharmacokinetics of ceftriaxone in pediatric patients with meningitis
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 1983-02
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 23
Issue 2
Start page 191
End page 194
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Pharmacokinetics of ceftriaxone after a single dose of 50 or 75 mg/kg were determined in 30 pediatric patients with bacterial meningitis. Data for doses of 50 and 75 mg/kg, respectively, were as follows (mean ± standard deviation): maximum plasma concentrations, 230 ± 64 and 295 ± 76 μg/ml; elimination rate constant, 0.14 ± 0.06 and 0.14 ± 0.04 h−1; harmonic elimination half-life, 5.8 ± 2.8 and 5.4 ± 2.1 h; plasma clearance, 51 ± 24 and 55 ± 18 ml/h per kg; volume of distribution, 382 ± 129 and 387 ± 56 ml/kg; mean concentration in cerebrospinal fluid 1 to 6 h after infusion, 5.4 and 6.4 μg/ml. A dosage schedule of 50 mg/kg every 12 h for bacterial meningitis caused by susceptible organisms is suggested for pediatric patients over 7 days of age.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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