Ceftriaxone for the treatment of serious infections

Steele, R. W. and Bradsher, R. W. (1983) Ceftriaxone for the treatment of serious infections. American Journal of Diseases of Children, 137 11: 1044-1047.

Author Steele, R. W.
Bradsher, R. W.
Title Ceftriaxone for the treatment of serious infections
Journal name American Journal of Diseases of Children   Check publisher's open access policy
ISSN 0002-922X
Publication date 1983
Sub-type Article (original research)
Volume 137
Issue 11
Start page 1044
End page 1047
Total pages 4
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract Ceftriaxone is an investigational cephalosporin with a half-life of five to eight hours. In an uncontrolled study, we evaluated its efficacy and safety in 30 pediatric and 12 young adult patients with serious bacterial infections. This agent was administered to children at a dosage of 50 to 75 mg/kg/day intravenously in two divided doses. Those with CNS infections received 100 mg/kg/day. In adults, the dosage was 1 g either once or twice daily. The diseases we treated included pneumonia (17), sepsis (eight), ventriculoperitoneal shunt infections (three), osteomyelitis (three), brain abscess (two), peritonitis (two), and miscellaneous (seven). Clinical cures were achieved in all cases, although one child with cystic fibrosis and Pseudomonas pneumonia had persistent colonization in his sputum. No serious side effects were observed. Although not the agent of choice for many of these pathogens, ceftriaxone appears to represent an important alternative to therapy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Journal title since 1994: Archives of Pediatrics and Adolescent Medicine (1072-4710; 1538-3628)

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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