Immunological responses following serial skin testing

Steele, Russell W., Crabtree, Bruce L., Smith, G. Richard and Marmer, Daniel J. (1986) Immunological responses following serial skin testing. Journal of Immunological Methods, 86 2: 213-216. doi:10.1016/0022-1759(86)90455-2

Author Steele, Russell W.
Crabtree, Bruce L.
Smith, G. Richard
Marmer, Daniel J.
Title Immunological responses following serial skin testing
Journal name Journal of Immunological Methods   Check publisher's open access policy
ISSN 0022-1759
Publication date 1986
Sub-type Article (original research)
DOI 10.1016/0022-1759(86)90455-2
Volume 86
Issue 2
Start page 213
End page 216
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Twenty volunteers underwent intradermal skin testing with tetanus toxoid (TT) and varicella-zoster (VZ) antigens weekly for 7 weeks. In addition to measurements of delayed hypersensitivity skin test responses, in vitro antigen specific lymphocyte stimulation and antibody levels were monitored. Data for TT exhibited more variability than VZ, demonstrating a marked boost in antibody titers after the first skin test and a shift in the kinetics of the skin test reaction to later maximum responsed after the first 3 weeks. In contrast, serial skin testing with VZ was not associated with changes in cellular immune assays. Following the initial VZ skin test there was a slight rise in antibody levels for one-third of studied individuals. These observations suggest that VZ skin test antigen is ideal for monitoring immune function and that repeated testing should not significantly influence in vitro assays.
Keyword Skin testing
Delayed hypersensitivity
Cellular immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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