Intravenous immunoglobulin: New clinical applications

Steele, R. W. and Burks, A. W. (1988) Intravenous immunoglobulin: New clinical applications. Annals of Allergy, 60 2: 89-94.

Author Steele, R. W.
Burks, A. W.
Title Intravenous immunoglobulin: New clinical applications
Journal name Annals of Allergy   Check publisher's open access policy
ISSN 0003-4738
Publication date 1988-02
Sub-type Critical review of research, literature review, critical commentary
Volume 60
Issue 2
Start page 89
End page 94
Total pages 6
Place of publication New York, United States
Publisher Elsevier
Language eng
Abstract At the present time there are three commercially available intravenous immunoglobulin (IVIG) preparations. There is no distinct therapeutic advantage for any one product over any other. Intravenous immunoglobulin is currently approved for the treatment of antibody deficiency syndromes and for acute and chronic idiopathic thrombocytopenic purpura. In addition, controlled clinical trials have demonstrated efficacy for the treatment of Kawasaki disease and for the prevention of the following infections: sepsis in preterm neonates, sepsis in infants with AIDS, and cytomegalovirus infection in the immune-compromised host. Open (uncontrolled) studies have suggested benefit in the treatment of neonatal sepsis, chronic Epstein-Barr virus infection, and a number of autoimmune diseases. Additional carefully designed studies must be completed before IVIG therapy can be recommendend for these latter categories. In published reports, dosage of IVIG and intervals between infusions have varied considerably. For all current indications, the physician must therefore individualize treatment and thoroughly review any recent literature that may clarify guidelines to IVIG therapy. Significant adverse reactions are rare but high cost remains the main obstacle to more routine implementation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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