Clinical applications of chemiluminescence of granulocytes

Steele, Russell W. (1991) Clinical applications of chemiluminescence of granulocytes. Reviews of Infectious Diseases, 13 5: 918-925.


Author Steele, Russell W.
Title Clinical applications of chemiluminescence of granulocytes
Journal name Reviews of Infectious Diseases   Check publisher's open access policy
ISSN 0162-0886
Publication date 1991-09
Sub-type Critical review of research, literature review, critical commentary
Volume 13
Issue 5
Start page 918
End page 925
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract The oxidative metabolic activity of granulocytes can be directly examined by chemiluminescence, a laboratory technique that measures photon emission during well-defined inflammatory or microbicidal events. Numerous studies have utilized chemiluminescence to examine early changes during infectious diseases and other pathologic processes. Studies have suggested that receptors on cell surfaces and oxygenation of granulocytes can reflect the severity of disease as well as provide early diagnostic information. Diseases within virtually every subspecialty of medicine have been studied in this respect, but most investigations have focused on infectious and autoimmune conditions. The present review summarizes current progress in laboratory methods and evaluates the potential application of recently published clinical data. It is apparent that during disease myeloperoxidase- and oxidase-dependent oxygenation activities reflect separate host responses, and independent measurements of these activities will offer a more meaningful understanding of host defense. Immune complexes and other factors in serum may also interact with granulocytes to alter the receptors on cell surfaces and subsequent metabolic activity. In some circumstances, enhanced function of granulocytes may be detrimental to the host.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Journal title since 1992: Clinical Infectious Diseases (1058-4838; 1537-6591)

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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