Cellular immunity in gnotobiotic primates induced by transfer factor

Eichberg, Jorg W., Steele, Russell W., Kalter, S. S., Kniker, William T., Heberling, R. L., Eller, Jerry J. and Rodriguez, Arthur R. (1976) Cellular immunity in gnotobiotic primates induced by transfer factor. Cellular Immunology, 26 1: 114-119. doi:10.1016/0008-8749(76)90353-1


Author Eichberg, Jorg W.
Steele, Russell W.
Kalter, S. S.
Kniker, William T.
Heberling, R. L.
Eller, Jerry J.
Rodriguez, Arthur R.
Title Cellular immunity in gnotobiotic primates induced by transfer factor
Journal name Cellular Immunology   Check publisher's open access policy
ISSN 0008-8749
1090-2163
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1016/0008-8749(76)90353-1
Volume 26
Issue 1
Start page 114
End page 119
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
Human dialyzable transferfactor (TF) was found capable of inducing in vivo (skin test) and in vitro blastogenesis) cellularimmunity in gnotobiotic nonhuman primates. Because the animals were gnotobiotic (germ-free) and had not been skin tested previously, these data support the hypothesis that induction of cell-mediated immunity in recipients of TF does not require a “priming” exposure to specific and/or cross-reacting antigens, and that this induction may be due to an antigen-specific informational effect of TF.

In addition, these results support the antigenic specificity of TF, in that recipient primates developed cellular reactivity only against donor “positive” but not against donor “negative” antigens.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published under Short communication

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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