Cerebral blood-flow and edema following carotid occlusion in the gerbil

Crockard, A., Iannotti, F., Hunstock, A.T., Smith, R.D., Harris, R.J. and Symon, L. (1980) Cerebral blood-flow and edema following carotid occlusion in the gerbil. Stroke, 11 5: 494-498.

Author Crockard, A.
Iannotti, F.
Hunstock, A.T.
Smith, R.D.
Harris, R.J.
Symon, L.
Title Cerebral blood-flow and edema following carotid occlusion in the gerbil
Journal name Stroke   Check publisher's open access policy
ISSN 0039-2499
1524-4628
Publication date 1980
Sub-type Article (original research)
Volume 11
Issue 5
Start page 494
End page 498
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
A technique for measuring focal cerebral blood flow (CBF) and brain specific gravity (SG) in gerbils is described; CO2 reactivity and autoregulation were tested. The mean CBF was 29.5 ± 4.5 ml/100 gm/min and brain SG 1.0500 ± 0.0004. Unilateral carotid occlusion resulted in a reduction of flow to 12.8 ± 5.8 ml/100 gm/min in the ipsilateral hemisphere with little change in the contralateral hemisphere; there was also a decrease in brain SG. One hour after occlusion, brain edema, as judged by decreased SG, developed at CBF less than 20 ml/100 gm/min and reached maximal levels at 7 ± 2 ml/100 gm/min. The amount of edema appeared to be related chiefly to the residual post-occlusion flow. With bilateral occlusion, CBF was close to zero and there was no change in SG, indicating that in the 'no flow' situation, there is no edema.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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