Immune deficiency in fetal alcohol syndrome

Johnson, Sharron, Knight, Richard, Marmer, Daniel J. and Steele, Russell W. (1981) Immune deficiency in fetal alcohol syndrome. Pediatric Research, 15 6: 908-911. doi:10.1203/00006450-198106000-00005


Author Johnson, Sharron
Knight, Richard
Marmer, Daniel J.
Steele, Russell W.
Title Immune deficiency in fetal alcohol syndrome
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 1981
Sub-type Article (original research)
DOI 10.1203/00006450-198106000-00005
Volume 15
Issue 6
Start page 908
End page 911
Total pages 4
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Summary: In a review of 13 documented cases of fetal alcohol syndrome (FAS), an increased incidence of life-threatening bacterial infections as well as a propensity to minor infections was observed. Five of 13 patients had had at least one episode of pneumonia, two had meningitis, and one had sepsis. A comprehensive immunologic evaluation of FAS was completed, and results were compared to an age-matched control group of children with intrauterine growth retardation without FAS.
Children with FAS were shown to have decreased E rosette-forming lymphocytes (35 ± 5% versus 55 ± 5% or 1328 ± 274 versus 2333 ± 112 per mm3), low EAC rosette-forming lymphocytes (15 ± 2% versus 18 ± 1% or 524 ± 109 versus 740 ± 75 per mm3), and diminished mitogen-induced stimulation responses to mitogens: 31616 ± 5337 versus 58076 ± 4455 cpm for phytohemagglutinin, 17582 ± 5436 versus 35018 ± 5346 for pokeweed mitogen, and 32460 ± 7044 versus 54996 ± 5531 for concanavalin A, P < 0.05. Nine patients had dysgammaglobulinemia. FAS subjects also had a marked eosinophilia (624 ± 154 versus 72 ± 27 mm3). Other parameters of immune function including absolute lymphocyte and neutrophil counts, total hemolytic complement, delayed cutaneous hypersensitivity, and nitroblue tetrazolium dye reduction assays, were not different from control children. Impairment of immunity may explain an increased susceptibility to infection in FAS.
Speculation: Defects in host defense and propensity to infection are attributable to intrauterine exposure to high levels of alcohol. Such abnormalities are not related to the degree of postnatal growth retardation nor to degree of malnutrition and do not correct with increasing age. Subsequent disease processes associated with defects in immunity such as malignancy or autoimmunity could result from this exposure to alcohol during fetal development.
Keyword Fetal alcohol syndrome
Immunity
Meningitis
Pneumonia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 133 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 16 Jun 2011, 11:16:03 EST by System User on behalf of School of Medicine