Immune-responses to varicella-zoster in the aged

Burke, B. L., Steele, R. W., Beard, O. W., Wood, J. S., Cain, T. D. and Marmer, D. J. (1982) Immune-responses to varicella-zoster in the aged. Archives of Internal Medicine, 142 2: 291-293. doi:10.1001/archinte.1982.00340150091017

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Author Burke, B. L.
Steele, R. W.
Beard, O. W.
Wood, J. S.
Cain, T. D.
Marmer, D. J.
Title Immune-responses to varicella-zoster in the aged
Journal name Archives of Internal Medicine   Check publisher's open access policy
ISSN 0003-9926
Publication date 1982
Sub-type Article (original research)
DOI 10.1001/archinte.1982.00340150091017
Open Access Status File (Publisher version)
Volume 142
Issue 2
Start page 291
End page 293
Total pages 3
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract Skin test reactivity and in vitro lymphocyte stimulation responses to varicella-zoster (VZ) were examined in a large normal population ranging in age from 6 months to 93 years. Waning of cellular immunity, as examined by skin delayed hypersensitivity, began at age 40 years. Skin test responses to phytohemagglutinin, however, remained positive into the eighth decade of life. In vitro lymphocyte stimulation responses to VZ were usually positive (stimulation index ≥2.5) until age 60 years, after which time levels, as observed with nonimmune individuals, were often demonstrated. Antibody levels, as measured by fluorescent antibody to membrane antigen, remained positive into the ninth and tenth decades of life. This was especially so with a history of reactivation (zoster) VZ infections, while skin test and in vitro responses were rarely positive in those individuals. Thus cellular, as contrasted with humoral, immunity decreases with advancing age, which may account for a propensity to reactivation of VZ virus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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