Localised immune complexes and slipped upper femoral epiphysis

Morrissy, R. T., Steele, R. W. and Gerdes, M. H. (1983) Localised immune complexes and slipped upper femoral epiphysis. Journal of Bone and Joint Surgery: British Volume, 65 5: 574-579.

Author Morrissy, R. T.
Steele, R. W.
Gerdes, M. H.
Title Localised immune complexes and slipped upper femoral epiphysis
Journal name Journal of Bone and Joint Surgery: British Volume   Check publisher's open access policy
ISSN 0301-620X
2044-5377
Publication date 1983
Sub-type Article (original research)
Volume 65
Issue 5
Start page 574
End page 579
Total pages 6
Place of publication London, United Kingdom
Publisher British Editorial Society of Bone and Joint Surgery
Language eng
Abstract Slipped upper femoral epiphysis remains a disease of unknown aetiology. Recent evidence has bolstered speculation that the immune system may play a role in the aetiology or pathogenesis of slipped epiphysis or of one of its complications, chondrolysis. This study reports the finding of immune complexes in the synovial fluid of all but one hip affected with slipped epiphysis in a consecutive series. In seven patients, immune complexes were detected by both the Raji cell assay and C1q-binding assay; in two, by the C1q-assay only; and in one, by the Raji cell assay only. No patients had immune complexes in the serum. Twenty-one patients with synovitis of the knee or hip caused by a variety of disorders served as the control group. Two of these patients had immune complexes in their synovial fluid. It appears that the immune complexes characterise the synovitis found with slipped upper femoral epiphysis as distinct from most other synovitides.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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