Response to pneumococcal vaccine in renal allograft recipients

Arnold, W. C., Steele, R. W., Rastogi, S. P. and Flanigan, W. J. (1985) Response to pneumococcal vaccine in renal allograft recipients. American Journal of Nephrology, 5 1: 30-34. doi:10.1159/000166899


Author Arnold, W. C.
Steele, R. W.
Rastogi, S. P.
Flanigan, W. J.
Title Response to pneumococcal vaccine in renal allograft recipients
Journal name American Journal of Nephrology   Check publisher's open access policy
ISSN 0250-8095
1421-9670
Publication date 1985
Sub-type Article (original research)
DOI 10.1159/000166899
Volume 5
Issue 1
Start page 30
End page 34
Total pages 5
Place of publication Basel, Switzerland
Publisher Karger
Language eng
Abstract Pneumococcal vaccine, 14-valent, was administered to 75 stable adult renal transplant patients on maintenance immunosuppression. 32 had undergone splenectomy prior to transplantation and 43 had not. Functional opsonizing antibody was measured by chemiluminescence methodology for types 12F and 14, contained in the vaccine, and for type 5, a control strain. Serum was examined prior to and at 1 and 6 months after vaccine injection. 33, 71, and 35% of transplant patients had preexisting antibody to types 5, 12F, and 14, respectively, as compared to 58, 87, and 68% of controls. No differences were observed in nonsplenectomized versus splenectomized patients. Following immunization, 59 and 76% of antibody-negative patients converted to positive for pneumococcus type 12F and 14. These included 70 and 70% for nonsplenectomized patients as compared to 50 and 84% for those splenectomized. Vaccination did not result in the production of opsonizing antibody for the related type 5 pneumococcus. Pneumococcal vaccine generates functional antibody and is safe in renal transplant patients.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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