Influence of operations with cardiopulmonary bypass on polymorphonuclear leukocyte function in infants

Burrows, F. A., Steele, R. W., Marmer, D. J., Vandevanter, S. H. and Westerman, G. R. (1987) Influence of operations with cardiopulmonary bypass on polymorphonuclear leukocyte function in infants. Journal of Thoracic and Cardiovascular Surgery, 93 2: 253-260.

Author Burrows, F. A.
Steele, R. W.
Marmer, D. J.
Vandevanter, S. H.
Westerman, G. R.
Title Influence of operations with cardiopulmonary bypass on polymorphonuclear leukocyte function in infants
Journal name Journal of Thoracic and Cardiovascular Surgery   Check publisher's open access policy
ISSN 0022-5223
1097-685X
Publication date 1987-02-01
Sub-type Article (original research)
Volume 93
Issue 2
Start page 253
End page 260
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract To determine the effect of operations with cardiopulmonary bypass on the immunologic function of polymorphonuclear leukocytes in infants, we studied polymorphonuclear leukocyte function and immunologic profile in 16 infants undergoing repair of congenital heart lesions. An oxygen/air/high-dose fentanyl anesthetic was used for all patients. Absolute neutrophil count increased significantly (p less than 0.05) after bypass and remained increased 48 hours afterward. Chemotaxis, random migration of polymorphonuclear leukocytes, and phagocytic index were unaffected, but bactericidal capacity decreased significantly immediately after cardiopulmonary bypass and remained decreased 48 hours later. Serum opsonizing capacity to bacterial and fungal antigens was variably altered, and complement factors 3 and 4 decreased significantly after cardiopulmonary bypass. Total hemolytic complement decreased significantly immediately after cardiopulmonary bypass and returned to normal by 48 hours. These data suggest that operations with cardiopulmonary bypass in infants significantly affect the immunologic function of polymorphonuclear leukocytes and result in consumption of complement.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 16 Jun 2011, 21:07:09 EST by System User on behalf of School of Medicine