Effect of prolonged modified fasting in obese persons on in vitro markers of immunity: Lymphocyte function and serum effects on normal neutrophils

McMurray, R. W., Bradsher, R. W., Steele, R. W. and Pilkington, N. S. (1990) Effect of prolonged modified fasting in obese persons on in vitro markers of immunity: Lymphocyte function and serum effects on normal neutrophils. American Journal of the Medical Sciences, 299 6: 379-385. doi:10.1097/00000441-199006000-00005


Author McMurray, R. W.
Bradsher, R. W.
Steele, R. W.
Pilkington, N. S.
Title Effect of prolonged modified fasting in obese persons on in vitro markers of immunity: Lymphocyte function and serum effects on normal neutrophils
Journal name American Journal of the Medical Sciences   Check publisher's open access policy
ISSN 0002-9629
1538-2990
Publication date 1990-06
Sub-type Article (original research)
DOI 10.1097/00000441-199006000-00005
Volume 299
Issue 6
Start page 379
End page 385
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract The effects of nutritional manipulation on immune function have been extensively studied in animals, but few studies have examined dietary restriction in humans. Obese patients enrolled in a protein-sparing, calorically restricted diet were monitored over a 3-month period with in vitro examination of mitogen- and antigen-induced lymphocyte blastogenesis. The sera from these patients were evaluated for effects on neutrophil chemotaxis, phagocytosis and microbial killing. Significant changes in body weight, triglycerides and glucose occurred during the diet, and most patients exhibited urinary ketosis. The diet was associated with increased blastogenesis in un-stimulated cultures and in varicella and Candida antigen-stimulated cultures, but blastogenesis was unchanged for phytohemagglutinin, concanavalin A, SK-SD and histoplasma. In assays of serum effects on neutrophil function, patients with urinary ketosis had depression of chemotaxis and microbial killing but not phagocytosis when compared to baseline or nonketotic patients. This study indicates that long-term caloric restriction is associated with significant effects on in vitro lymphocyte stimulation and with significant serum effects on normal neutrophil function.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 16 Jun 2011, 11:05:21 EST by System User on behalf of School of Medicine