T-lymphocyte subsets in nephrotic syndrome

Fiser, Richard T, Arnold, Watson C., Charlton, Ronald K., Steele, Russell W., Childress, Sherri H. and Shirkey, Belinda (1991) T-lymphocyte subsets in nephrotic syndrome. Kidney International, 40 5: 913-916. doi:10.1038/ki.1991.293

Author Fiser, Richard T
Arnold, Watson C.
Charlton, Ronald K.
Steele, Russell W.
Childress, Sherri H.
Shirkey, Belinda
Title T-lymphocyte subsets in nephrotic syndrome
Journal name Kidney International   Check publisher's open access policy
ISSN 0085-2538
Publication date 1991-11
Sub-type Article (original research)
DOI 10.1038/ki.1991.293
Volume 40
Issue 5
Start page 913
End page 916
Total pages 4
Place of publication London, United Kingdom
Publisher Nature
Language eng
Formatted abstract
T-lymphocyte subsets in nephrotic syndrome. T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 plusminus 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P < 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P < 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS.
Keyword T-lymphocyte
Nephrotic syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 51 times in Thomson Reuters Web of Science Article | Citations
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