Culture-negative osteomyelitis

Floyed, R. L. and Steele, R. W. (2003) Culture-negative osteomyelitis. Pediatric Infectious Disease Journal, 22 8: 731-735.

Author Floyed, R. L.
Steele, R. W.
Title Culture-negative osteomyelitis
Journal name Pediatric Infectious Disease Journal   Check publisher's open access policy
ISSN 0891-3668
Publication date 2003-08
Sub-type Article (original research)
Volume 22
Issue 8
Start page 731
End page 735
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objective: To examine the natural history, clinical manifestations, laboratory changes and outcomes of children with culture-negative osteomyelitis and to compare findings with cases of culture-positive infection treated during the same time period.

Design: Retrospective review of consecutive admissions for osteomyelitis during the 4-year period 1998 through 2001, with a minimum follow-up of 1 year.

Setting: A single urban children's hospital with a large orthopedic referral service.

Clinical and laboratory measures: Age, gender, predisposing factors, clinical manifestations, maximum temperature, duration of pain, bone involved, laboratory changes, results of cultures from infected bone and blood and outcome after treatment.

Results: A total of 85 patients fulfilled study criteria, of whom 40 were culture-negative. Compared with culture-positive cases, culture-negative osteomyelitis patients were less likely to have antecedent trauma (P = 0.0357) and overlying skin changes (P = 0.0001), duration of pain and other symptoms was longer (P = 0.0396) and skeletal residua were rare. They were also older, with this difference approaching statistical significance (P = 0.0586).

Conclusions: Children with culture-negative osteomyelitis present initially differently from culture-positive cases and can be managed as presumed staphylococcal disease with excellent long term results.
Keyword Osteomyelitis
Bone infection
Bacterial infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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