Pulmonary resection of metastatic hepatocellular carcinoma after liver transplantation

Bates, Michael J., Farkas, Emily, Taylor, David and McFadden, P. Michael (2008) Pulmonary resection of metastatic hepatocellular carcinoma after liver transplantation. Annals of Thoracic Surgery, 85 2: 412-415. doi:10.1016/j.athoracsur.2007.10.065

Author Bates, Michael J.
Farkas, Emily
Taylor, David
McFadden, P. Michael
Title Pulmonary resection of metastatic hepatocellular carcinoma after liver transplantation
Journal name Annals of Thoracic Surgery   Check publisher's open access policy
ISSN 0003-4975
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1016/j.athoracsur.2007.10.065
Volume 85
Issue 2
Start page 412
End page 415
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract Background The primary limitation to long-term survival after liver transplantation for hepatocellular carcinoma (HCC) is tumor recurrence. Pulmonary resection for metastatic HCC prolongs survival in patients after liver resection; this success may be extrapolated to the transplant population in the treatment of pulmonary recurrence of HCC after liver transplantation. Methods Between January 2000 and January 2006, five patients who underwent orthotopic liver transplantation for HCC were identified on routine follow-up with pulmonary metastases. They all underwent resection of the pulmonary recurrence of HCC and were studied retrospectively. Results The time from transplant to diagnosis of pulmonary recurrence ranged from 150 days to 880 days, with a mean of 500 days. All of the recurrences were amenable to complete resection. Two patients developed a second tumor. One patient had a new primary of squamous cell carcinoma. Another patient had a bony recurrence of HCC in the ninth rib. Four of the patients are still alive, and the fifth died from hepatic failure. The stage of the tumor in the explanted liver ranged from II to IVb. The average time for survival from transplant was 44 months, and the average time from pulmonary resection was 27.5 months. Conclusions The patients in this study demonstrate survival times similar to patients with HCC treated with liver resection. Although the size of the study population is small, the long survival times in the patients is encouraging. The advanced stage and histologically invasive nature of the primary tumors may predispose to subsequent pulmonary recurrence.
Keyword Extrahepatic Metastases
Surgical Resection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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