Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization

Leggat, Jamie A., Gibbons, Deena L., Haque, Syeda F. Y., Smith, Adrian L., Wells, James W., Choy, Katherine, Lloyd, Clare M., Hayday, Adrian C. and Noble, Alistair (2008) Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. Journal of Allergy and Clinical Immunology, 122 5: 1014-1021. doi:10.1016/j.jaci.2008.08.011

Author Leggat, Jamie A.
Gibbons, Deena L.
Haque, Syeda F. Y.
Smith, Adrian L.
Wells, James W.
Choy, Katherine
Lloyd, Clare M.
Hayday, Adrian C.
Noble, Alistair
Title Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2008-11
Sub-type Article (original research)
DOI 10.1016/j.jaci.2008.08.011
Volume 122
Issue 5
Start page 1014
End page 1021
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract

Infection or stimulation of the innate immune system by nonspecific microbial antigens is thought to educate the immune system to respond appropriately to allergens, preventing allergy.

To determine the immunologic pathways that might explain how infection/microbial exposure inhibits allergic sensitization.

Immunologic studies of non–antigen-specific functions of CD8 memory cells, their maturation in vivo, and their effects in a mouse asthma model, to test the hypothesis that CD8 memory is shaped by innate immunity in a way that can inhibit allergic disease.

We found that CD8 memory T-cell (CD8 Tm) populations bridge innate and adaptive immunity by responding to either antigen or cytokines alone. CD8 Tm populations partially subvert the clonal selection process by activating their neighbors through induction of dendritic cell IL-12. Stimulation of innate or acquired immunity in the lung or gut causes expansion/maturation of CD8 Tm populations, which provide an early source of cytokines, enhance TH1 immunity, and inhibit allergic sensitization and airway inflammation/hyperresponsiveness in a non–antigen-specific fashion.

CD8 T-cell–mediated immune memory is long-lived and can retain its capacity for rapid cytokine release in a nonantigen-specific fashion. This novel type of memory enhances TH1 over TH2 immunity and prevents allergic sensitization after exposure to environmental antigens or infection.
Keyword CD8 T cell
immunologic memory
innate immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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