Evolutionary conservation of neuropeptide expression in the thymus of different species

Silva, Alberto B., Aw, Danielle and Palmer, Donald B. (2006) Evolutionary conservation of neuropeptide expression in the thymus of different species. Immunology, 118 1: 131-140. doi:10.1111/j.1365-2567.2006.02351.x


Author Silva, Alberto B.
Aw, Danielle
Palmer, Donald B.
Title Evolutionary conservation of neuropeptide expression in the thymus of different species
Journal name Immunology   Check publisher's open access policy
ISSN 0019-2805
1365-2567
Publication date 2006-05
Sub-type Article (original research)
DOI 10.1111/j.1365-2567.2006.02351.x
Volume 118
Issue 1
Start page 131
End page 140
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Evidence suggests that the immune and neuroendocrine systems cross talk by sharing ligands and receptors. Hormones and neuropeptides produced by the neuroendocrine system often modulate the function of lymphoid organs and immune cells. We have previously reported the intrathymic expression of somatostatin (SOM) in the mouse and that several neuropeptides, most notably calcitonin-gene-related peptide (CGRP), neuropeptide Y (NPY), SOM and substance P (SP), can modulate thymocyte development. However, little is known about the intrathymic expression of these neuropeptides either in the mouse or in other species. Moreover, a comparative analysis of the expression of these molecules would highlight the evolutionary importance of intrathymic neuroendocrine interactions in T-cell development. We have studied the expression of different neuropeptides in the thymus of zebrafish, Xenopus, avians, rodent, porcine, equine and human by immunohistochemistry and reverse transcription-polymerase chain reaction. We found that CGRP, NPY, SOM, SP and vasointestinal polypeptide (VIP) are expressed in the thymus of all species investigated. The thymic location of many of these neuropeptides was conserved and appears to be within the stromal compartments. Interestingly, in the avian thymus the expression of CGRP, SOM and SP appears to change depending on the age of the tissue. These findings suggest that neuropeptides may play an important role in T-cell development and provide further evidence of cross talk between the immune and neuroendocrine systems.
© 2006 Blackwell Publishing Ltd.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Fri, 27 May 2011, 14:45:36 EST by Susan Allen on behalf of Institute for Molecular Bioscience