Immunosenescence: Emerging challenges for an ageing population

Aw, Danielle, Silva, Alberto B. and Palmer, Donald B. (2007) Immunosenescence: Emerging challenges for an ageing population. Immunology, 120 4: 435-446. doi:10.1111/j.1365-2567.2007.02555.x

Author Aw, Danielle
Silva, Alberto B.
Palmer, Donald B.
Title Immunosenescence: Emerging challenges for an ageing population
Journal name Immunology   Check publisher's open access policy
ISSN 0019-2805
Publication date 2007-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1365-2567.2007.02555.x
Volume 120
Issue 4
Start page 435
End page 446
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract It is now becoming apparent that the immune system undergoes age-associated alterations, which accumulate to produce a progressive deterioration in the ability to respond to infections and to develop immunity after vaccination, both of which are associated with a higher mortality rate in the elderly. Immunosenescence, defined as the changes in the immune system associated with age, has been gathering interest in the scientific and health-care sectors alike. The rise in its recognition is both pertinent and timely given the increasing average age and the corresponding failure to increase healthy life expectancy. This review attempts to highlight the age-dependent defects in the innate and adaptive immune systems. While discussing the mechanisms that contribute to immunosenescence, with emphasis on the extrinsic factors, particular attention will be focused on thymic involution. Finally, we illuminate potential therapies that could be employed to help us live a longer, fuller and healthier life. © 2007 The Authors.
Keyword Ageing
Thymic involution
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 226 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 27 May 2011, 14:38:21 EST by Susan Allen on behalf of Institute for Molecular Bioscience