Is thymocyte development functional in the aged?

Aw, Danielle, Silva, Alberto B. and Palmer, Donald B. (2009) Is thymocyte development functional in the aged?. Aging, 1 2: 146-153.

Author Aw, Danielle
Silva, Alberto B.
Palmer, Donald B.
Title Is thymocyte development functional in the aged?
Journal name Aging   Check publisher's open access policy
ISSN 1945-4589
Publication date 2009-02
Sub-type Article (original research)
Volume 1
Issue 2
Start page 146
End page 153
Total pages 9
Place of publication Online
Publisher Impact Journals LLC
Language eng
Abstract T cells are an integral part of a functional immune system with the majority being produced in the thymus. Of all the changes related to immunosenescence, regression of the thymus is considered one of the most universally recognised alterations. Despite the reduction of thymic size, there is evidence to suggest that T cell output is still present into old age, albeit much diminished; leading to the assumption that thymocyte development is normal. However, current data suggests that recent thymic emigrant from the aged thymus are functionally less responsive, giving rise to the possibility that the generation of naive T cell may be intrinsically impaired in the elderly. In light of these findings we discuss the evidence that suggest aged T cells may be flawed even before exiting to the periphery and could contribute to the age-associated decline in immune function.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published under Perspective

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 25 May 2011, 12:27:26 EST by Susan Allen on behalf of Institute for Molecular Bioscience