A potent inhibitor of osteoclastic bone-resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein- PTHRP[107-111]

Fenton, A.J., Kemp, B.E., Hammonds, R.G., Mitchelhill, K., Moseley, J.M., Martin, T.J. and Nicholson, G.C. (1991) A potent inhibitor of osteoclastic bone-resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein- PTHRP[107-111]. Endocrinology, 129 6: 3424-3426.


Author Fenton, A.J.
Kemp, B.E.
Hammonds, R.G.
Mitchelhill, K.
Moseley, J.M.
Martin, T.J.
Nicholson, G.C.
Title A potent inhibitor of osteoclastic bone-resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein- PTHRP[107-111]
Journal name Endocrinology   Check publisher's open access policy
ISSN 0013-7227
1945-7170
Publication date 1991-12
Sub-type Article (original research)
Volume 129
Issue 6
Start page 3424
End page 3426
Total pages 3
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Language eng
Abstract We have recently shown that a carboxyl-terminal sequence of parathyroid hormone-related protein, PTHrP[107–139], is a potent direct inhibitor of osteoclastic bone resorption. We now report that this bone resorption inhibitory activity, which we have called osteostatin, is entirely contained within the highly conserved pentapeptide PTHrP[107–l 11]. Our results indicate that processing at residue 106 and a free amino terminus is required for full activity of the peptide. The retroinverted peptide is considerably less potent than the parent peptide. The retention of full biological activity in such a short fragment was unexpected. This data provides the basis for the development of further analogs with potential therapeutic use in disorders associated with increased osteoclastic bone resorption.
Keyword Humoral hypercalcemia
Peptide
Prostaglandins
Expression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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