Carboxyl-terminal parathyroid hormone-related protein inhibits bone resorption by isolated chicken osteoclasts

Fenton, A.J., Martin, T.J. and Nicholson, G.C. (1994) Carboxyl-terminal parathyroid hormone-related protein inhibits bone resorption by isolated chicken osteoclasts. Journal of Bone and Mineral Research, 9 4: 515-519.


Author Fenton, A.J.
Martin, T.J.
Nicholson, G.C.
Title Carboxyl-terminal parathyroid hormone-related protein inhibits bone resorption by isolated chicken osteoclasts
Journal name Journal of Bone and Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 1994-04
Sub-type Article (original research)
Volume 9
Issue 4
Start page 515
End page 519
Total pages 5
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Carboxyl-terminal peptides from parathyroid hormone-related protein (PTHrP) have been studied for their effect on bone resorption by osteoclasts isolated from 15 day embryonic chickens. Basal bone resorption by chicken osteoclasts was directly inhibited by chicken and human PTHrP-(107–139) and the pentapeptide PTHrP-(107–111). The chicken and human analogs were equipotent. Both the number of resorption pits and the total area resorbed per bone slice were reduced by PTHrP-(107–139), but it did not alter the size of individual resorption pits. Resorption stimulated by hPTH-(1–34) in cocultures of chicken osteoclasts with osteoblasts was also inhibited by cPTHrP-(107–139) but required a concentration three orders of magnitude greater than that required to inhibit basal resorption in cocultures or cultures of isolated osteoclasts. The finding of resorption inhibitory activity by PTHrP-(107–139) in avian as well as mammalian species strengthens the hypothesis that carboxyl-terminal PTHrP may act as a paracrine regulator of bone cell activity.
Keyword Isolated rat osteoclasts
Calcitonin receptors
Prostaglandin-E2
Expression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 3 December 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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