Fracture thresholds revisited. Geelong osteoporosis study

Pasco, J. A., Seeman, E., Nicholson, G. C. and Kotowicz, M. A. (2002) Fracture thresholds revisited. Geelong osteoporosis study. Journal of Clinical Epidemiology, 55 7: 642-646. doi:10.1016/S0895-4356(02)00396-7


Author Pasco, J. A.
Seeman, E.
Nicholson, G. C.
Kotowicz, M. A.
Title Fracture thresholds revisited. Geelong osteoporosis study
Journal name Journal of Clinical Epidemiology   Check publisher's open access policy
ISSN 0895-4356
1878-5921
Publication date 2002-07
Sub-type Article (original research)
DOI 10.1016/S0895-4356(02)00396-7
Volume 55
Issue 7
Start page 642
End page 646
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract Osteoporosis, in the absence of fracture, is defined as a deficit in bone mineral density (BMD) of 2.5 SD or more below the young adult reference mean in postmenopausal Caucasian populations. BMD is a measure of fracture risk but not the sole predictor. We have assessed a combination of easily accessible measures of age, height, weight, and BMD to improve fracture risk assessment. Women with low trauma fractures and a control group were recruited from south-eastern Australia. Discriminant analysis derived multivariate equations that assessed fracture risk. Age was not in the best models at the spine and forearm sites. Weight and height contributed to the relationship for the forearm sites only. At the proximal femur, the BMD level that separates fracture cases from nonfracture cases, increases with age. These separation levels of BMD were higher than the WHO's level of osteoporosis (T-score < -2.5 SD) at ages older than 62 years. This increasing BMD threshold with age suggests that other age-related risk factors assume increasing importance among the elderly.
Keyword Fracture thresholds
Bone mineral density
Fracture prediction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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