Fracture risk (FRISK) score: Geelong osteoporosis study

Henry, Margaret Joy, Pasco, Julie Anne, Sanders, Kerrie Margaret, Nicholson, Geoffrey Charles and Kotowicz, Mark Anthony (2006) Fracture risk (FRISK) score: Geelong osteoporosis study. Radiology, 241 1: 190-196. doi:10.1148/radiol.2411051290

Author Henry, Margaret Joy
Pasco, Julie Anne
Sanders, Kerrie Margaret
Nicholson, Geoffrey Charles
Kotowicz, Mark Anthony
Title Fracture risk (FRISK) score: Geelong osteoporosis study
Journal name Radiology   Check publisher's open access policy
ISSN 0033-8419
Publication date 2006-10
Sub-type Article (original research)
DOI 10.1148/radiol.2411051290
Volume 241
Issue 1
Start page 190
End page 196
Total pages 7
Place of publication Oak Brook, IL, United States
Publisher Radiological Society of North America
Language eng
Abstract Purpose: To develop and evaluate a fracture risk (FRISK) score based on multiple-site bone mineral density (BMD) measurements and other risk factors, to enable prediction of future fracture occurrence. Materials and Methods: All participants gave written informed consent, and the study was approved by the Barwon Health Research and Ethics Advisory Committee. BMD was measured at the femoral neck and spine in two concurrently recruited groups: women 60 years of age or older who had sustained a low-trauma fracture of the hip, spine, humerus or distal forearm during a 2-year ascertainment period (n = 231; mean age, 74 years ± 7 [standard deviation]) and a population-based random sample of women who had not sustained a fracture during the recruitment period (n = 448; mean age, 72 years ± 8). Falls in the previous year and the number of self-reported fractures in adult life were recorded. Coefficients of a multiple logistic regression model were used as weightings for a combined model. A longitudinal population-based sample was used to assess the fracture risk equation (n = 600; median age, 74 years; interquartile range, 67–82 years). Results: The FRISK score was obtained from the following equation: 9.304 − 4.735BMDSP − 4.530BMDFN + 1.127FS + 0.344NPF + 0.037W, where BMDSP is spinal BMD (in grams per square centimeter), BMDFN is femoral neck BMD, FS is falls score, NPF is number of previous fractures, and W is weight (in kilograms). The FRISK score successfully predicted 75% of fractures 2 years after baseline measurements in subjects in the longitudinal study with 68% specificity. Conclusion: This study resulted in the derivation of a fracture risk score that successfully predicted 75% of fractures 2 years after baseline.
Keyword Bone-mineral Density
Hip Fracture
Vertebral Fracture
White Women
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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