Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study

Pasco, Julie A., Jacka, Felice N., Williams, Lana J., Henry, Margaret J., Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael (2008) Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study. Journal of Affective Disorders, 107 1-3: 221-225. doi:10.1016/j.jad.2007.07.024

Author Pasco, Julie A.
Jacka, Felice N.
Williams, Lana J.
Henry, Margaret J.
Nicholson, Geoffrey C.
Kotowicz, Mark A.
Berk, Michael
Title Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study
Journal name Journal of Affective Disorders   Check publisher's open access policy
ISSN 0165-0327
Publication date 2008-04
Sub-type Article (original research)
DOI 10.1016/j.jad.2007.07.024
Volume 107
Issue 1-3
Start page 221
End page 225
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Background: There is conflicting evidence regarding levels of leptin in depression. In this study we aimed to investigate the relationship between serum leptin level and depression in a community sample of women using both cross-sectional and longitudinal data. Methods: From among 510 women aged 20-78 yr, 83 were identified with a lifetime history of major depressive disorder or dysthymia, ascertained using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP). Serum leptin levels were measured by radioimmunoassay. Medication use and lifestyle were self-reported and body mass index (BMI) determined from measures of height and weight. Results: Using multiple linear regression, serum leptin levels were greater among women with a lifetime history of depression compared to women without any history of depression, independent of BMI. Adjusted geometric mean values of serum leptin were 16.37 (95%CI 14.70-18.23) ng/mL for depressed and 14.46 (95%CI 13.79-15.16) ng/mL for non-depressed women (P = 0.039). The hazard ratio (HR) for a de novo depressive disorder over five years increased 2.56-fold for each standard deviation increase in log-transformed serum leptin among non-smokers and this was not explained by differences in BMI, medications or other lifestyle factors (HR = 2.56, 95%CI 1.52-4.30). No association was observed for smokers. Limitations: There is potential for unrecognised confounding, recall bias and transient changes in body composition. Conclusion: Women with a lifetime history of depression have elevated levels of serum leptin, and elevated serum leptin predicts subsequent development of a depressive disorder.
Keyword Leptin
Risk factor
Body mass index
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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