Management of head and neck paragangliomas: Review of 120 patients

Papaspyrou, Konstantinos, Mann, Wolf J. and Amedee, Ronald G. (2009) Management of head and neck paragangliomas: Review of 120 patients. Head and Neck, 31 3: 381-387. doi:10.1002/hed.20967


Author Papaspyrou, Konstantinos
Mann, Wolf J.
Amedee, Ronald G.
Title Management of head and neck paragangliomas: Review of 120 patients
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2009-03
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/hed.20967
Volume 31
Issue 3
Start page 381
End page 387
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background. Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.
Methods and Results. A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88%of TT resections.
Conclusion. According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically.
Keyword Paraganglioma
Recurrence
Embolization
F-DOPA-PET
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 28 OCT 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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