Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis

Zhou, Fang, Leggatt, Graham R. and Frazer, Ian H. (2011) Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis. The Federation of European Biochemical Societies (FEBS) Journal, 278 6: 955-963. doi:10.1111/j.1742-4658.2011.08011.x


Author Zhou, Fang
Leggatt, Graham R.
Frazer, Ian H.
Title Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis
Formatted title
Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysis
Journal name The Federation of European Biochemical Societies (FEBS) Journal   Check publisher's open access policy
ISSN 0014-2956
1742-464X
1742-4658
Publication date 2011-04-01
Sub-type Article (original research)
DOI 10.1111/j.1742-4658.2011.08011.x
Volume 278
Issue 6
Start page 955
End page 963
Total pages 9
Place of publication Oxford, U.K.
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Infection of epithelium with human papillomavirus (HPV) 16 is generally prolonged, suggesting an ineffective virus-specific immune response, and prolonged infection promotes anogenital cancer. To determine whether poor antigen presentation by HPV-infected keratinocytes (KCs) contributes to prolonged HPV infection, KCs and KCs expressing HPV 16 E7 protein (E7-KCs) were compared for susceptibility to T-cell-mediated lysis directed to ovalbumin (OVA) processed for presentation by the KCs. Interferon (IFN)-γ efficiently enhanced susceptibility to lysis of KCs presenting OVA, but not of E7-KCs similarly presenting OVA. E7-KCs also exhibited impaired IFN-γ-induced upregulation of transcription of major histocompatibility complex class I antigen processing and presentation-associated genes, and of membrane SIINFEKL–H-2Kb complexes. Thus, expression of HPV 16 E7 protein in KCs may inhibit enhancement by IFN-γ of KC sensitivity to T-cell lysis, by impairing antigen presentation.
Keyword Antigen processing
CD8 T cells
Host-virus interactions
Papillomavirus
Regulatory factor-1
Cervical-carcinoma
Expression
Peptide
Oncoprotein
Genes
TAP
Activation
Induction
Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Wed, 18 May 2011, 23:00:06 EST by Dr Graham Leggatt on behalf of UQ Diamantina Institute