Omega-3 fatty acid supplementation in obesity: The effect on adiponectin, leptin and insulin sensitivity

Gray, B., Vitetta, L., Colquhoun, D. and Masci, P. (2011). Omega-3 fatty acid supplementation in obesity: The effect on adiponectin, leptin and insulin sensitivity. In: International Conference on the Science of Nutrition in Medicine and Healthcare, Sydney, Australia, (86-86). 13-15 May 2011.

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Author Gray, B.
Vitetta, L.
Colquhoun, D.
Masci, P.
Title of paper Omega-3 fatty acid supplementation in obesity: The effect on adiponectin, leptin and insulin sensitivity
Conference name International Conference on the Science of Nutrition in Medicine and Healthcare
Conference location Sydney, Australia
Conference dates 13-15 May 2011
Convener The Australasian College of Nutritional and Environmental Medicine (ACNEM) Inc, the Food and Nutritional Sciences Division of the CSIRO and the Nutrition Society of Australia (NSA)
Place of Publication Sydney, Australia
Publication Year 2011
Sub-type Published abstract
Start page 86
End page 86
Total pages 1
Collection year 2011
Language eng
Formatted Abstract/Summary
BACKGROUND: Obesity is associated with numerous comorbidities including type 2 diabetes mellitus, cardiovascular disease (CVD) and some cancers1,2. Obesity is independently associated with altered levels of biologically active proteins secreted by adipocytes, including the hormones adiponectin and leptin. Adiponectin has regulatory actions on energy homeostasis, fatty acid metabolism and insulin sensitivity3, whilst leptin serves as a short‐term adaptation to starvation, inhibiting feeding and increasing thermogenesis4. These adipokines are implicated in insulin resistance, hypertension and dyslipidemia, all of which are components of heart disease progression. With the high prevalence of CVD in the Western world, much attention has been given to the positive role of omega–3 fatty acids in the prevention and treatment of CVD. Current evidence suggests a dose dependent relationship exists between omega–3 fatty acid supplementation and changes in adiponectin and leptin levels5. This study aims to assess the effect of a high dose supplementation on these adipokines in overweight and obese individuals.
METHODS: This pilot trial will enrol 40 participants [BMI≥25], each given 2000 mg/day of a commercially available omega–3 fatty acid preparation (4000mg marine lipid) for an 8 week period. Blood samples will be taken at baseline, 4 and 8 weeks, assessing fasting levels of leptin, adiponectin, blood lipids, markers of insulin sensitivity, liver function and fatty acid indices. Physical activity, fatigue and diet will also be monitored at intervals throughout the study.
DISCUSSION: This abstract presentation will discuss preliminary data of the partially completed study not yet published . CONCLUSIONS: We propose that supplementation with omega–3 fatty acids will improve the levels of these adipokines with benefits to fatty acid indices, blood lipids and insulin sensitivity that may translate into a reduced risk of developing CVD, metabolic syndrome and diabetes.
References REFERENCES: 1 Haslam D, James W. Obesity. Lancet 2005;366:1197‐1209. 2 WHO. Obesity and overweight. Geneva: World Health Organisation;2003. 3 Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116:1784 ‐1792. 4 Jequier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002;967:379‐388. 5 Patel JV, Lee KW, Tomson J, et al. Effects of omega‐3 polyunsaturated fatty acids on metabolically active hormones in patients post‐myocardial infarction. Int J Cardiol 2007;115(1):42‐45.R
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Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Tue, 17 May 2011, 15:32:04 EST by Dr Luis Vitetta on behalf of Medicine - Princess Alexandra Hospital