Probiotics: An update

Vitetta, Luis (2011). Probiotics: An update. In: International Conference on the Science of Nutrition in Medicine and Healthcare, Sydney, Australia, (72-72). 13-15 May 2011.

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Author Vitetta, Luis
Title of paper Probiotics: An update
Conference name International Conference on the Science of Nutrition in Medicine and Healthcare
Conference location Sydney, Australia
Conference dates 13-15 May 2011
Convener The Australasian College of Nutritional and Environmental Medicine (ACNEM) Inc, the Food and Nutritional Sciences Division of the CSIRO and the Nutrition Society of Australia (NSA)
Place of Publication Sydney , Australia
Publication Year 2011
Sub-type Oral presentation
Start page 72
End page 72
Total pages 1
Collection year 2011
Language eng
Formatted Abstract/Summary
Microbiology is a cornerstone of medicine and although bacteria have been classically viewed as pathogenic, it is now well established that the majority of the interactions between the host and its microbial species are largely symbiotic.

A recent review has elegantly summarized the complexity that is the human microbiome of the gastrointestinal tract [1]. Lee and Mazmanian [1] explain how this partnership was forged over millennia of co–evolutionary interactions. They
demonstrate how molecular exchanges involving bacterial signals that are recognized by receptors on cells of the host mediate beneficial outcomes for the microbiome and the human host. Furthermore, it is reported that the adaptive immune system [specific aspects], are significantly influenced by the intestinal commensal bacteria. They conclude that a clear understanding of the molecular mechanisms that mediate the symbiotic existence between commensal bacteria and humans will re‚Äźcharacterize how the evolution of adaptive immunity is viewed and as a consequence how medicine will approach the treatment of numerous immunologic disorders.

Also recently, researchers from the U.S. have reported a study with a genetically engineered Lactobacillus acidophilus [2] that opens the way for probiotics to metamorphose an ancient remedy into a sophisticated 21st century therapeutic.

Probiotic formulations are widely available in Australian supermarkets and food stores. These products have an assortment of proposed beneficial effects, including promotion of gastrointestinal health. The maintenance of intestinal immune homeostasis involves a balance of metabolic interactions between the gastrointestinal microbiome, the gut epithelium, and the host’s array of immune tissues. This workshop will update the current science surrounding the
efficacy of probiotics.
Keyword Probiotics
Commensal bacteria
Innate immunity
References References: 1.Lee YK, Mazmanian SK. Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? Science 2010;330:1768 DOI:10.1126/science.1195568. 2.Mohamadzadeh M, Pfeilerb EA, Browna JB, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. PNAS 2011; Jan 31. [Epub ahead of print]
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Institutional Status UQ

Document type: Conference Paper
Collection: School of Medicine Publications
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Created: Mon, 16 May 2011, 20:58:20 EST by Dr Luis Vitetta on behalf of Medicine - Princess Alexandra Hospital