The application of photodynamic therapy in the treatment of metastatic endobronchial disease

Magro, Cynthia M., Abbas, Abbas E. and Ross, Patrick (2006) The application of photodynamic therapy in the treatment of metastatic endobronchial disease. Lasers in Surgery and Medicine, 38 5: 376-383. doi:10.1002/lsm.20309


Author Magro, Cynthia M.
Abbas, Abbas E.
Ross, Patrick
Title The application of photodynamic therapy in the treatment of metastatic endobronchial disease
Journal name Lasers in Surgery and Medicine   Check publisher's open access policy
ISSN 0196-8092
1096-9101
Publication date 2006-06
Sub-type Article (original research)
DOI 10.1002/lsm.20309
Volume 38
Issue 5
Start page 376
End page 383
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background and Objective: We utilized photodynamic therapy (PDT) for palliation of metastatic endobronchial tumors employing sensitization with synthetic porphyrin, application of non-thermal light, and endoscopic debridement of necrotic tumor.
Study Design/Materials and Methods: Nine patients with symptomatic endobronchial metastasis from carcinomas of the colon(3), breast(3), kidney(2), and tongue(1) received PDT.
Results
: After two PDT treatments, patients showed substantial response, which was complete in all but one. One patient had perioperative complications and expired 2 days after developing massive hemoptysis during tumor debridement. Patient survival was 6.38 months (mean) and 4.2 months (median). Most patients died from advanced metastatic disease. One patient with metastasis limited to the airway is still alive 24 months following endobronchial presentation.
Conclusions: PDT ameliorates symptoms of metastatic airway obstruction, is easy to apply, has low morbidity and improves the quality of life.
Keyword Bronchial metastasis
Lung Cancer
Laser
Nd-yag Laser
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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