The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation

Royce-Tolland, Morgan E., Andersen, Angela A., Koyfman, Hannah R., Talbot, Dale J., Wutz, Anton, Tonks, Ian D., Kay, Graham F. and Panning, Barbara (2010) The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation. Nature Structural and Molecular Biology, 17 8: 948-954. doi:10.1038/nsmb.1877


Author Royce-Tolland, Morgan E.
Andersen, Angela A.
Koyfman, Hannah R.
Talbot, Dale J.
Wutz, Anton
Tonks, Ian D.
Kay, Graham F.
Panning, Barbara
Title The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation
Journal name Nature Structural and Molecular Biology   Check publisher's open access policy
ISSN 1545-9993
1545-9985
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1038/nsmb.1877
Volume 17
Issue 8
Start page 948
End page 954
Total pages 7
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
One X chromosome, selected at random, is silenced in each female mammalian cell. Xist encodes a noncoding RNA that influences the probability that the cis-linked X chromosome will be silenced. We found that the A-repeat, a highly conserved element within Xist, is required for the accumulation of spliced Xist RNA. In addition, the A-repeat is necessary for X-inactivation to occur randomly. In combination, our data suggest that normal Xist RNA processing is important in the regulation of random X-inactivation. We propose that modulation of Xist RNA processing may be part of the stochastic process that determines which X chromosome will be inactivated.
© 2010 Nature America, Inc. All rights reserved.
Keyword RNA processing
X-inactivation
A-repeat
Random choice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Fri, 29 Apr 2011, 16:33:45 EST by Anne Louise Bulloch on behalf of Medicine - Royal Brisbane and Women's Hospital