A single nucleotide polymorphism-derived regulatory gene network underlying puberty in 2 tropical breeds of beef cattle

Fortes, M. R. S., Reverter, A., Nagaraj, S. H., Zhang, Y., Jonsson, N. N., Barris, W., Lehnert, S., Boe-Hansen, G. B. and Hawken, R. J. (2011) A single nucleotide polymorphism-derived regulatory gene network underlying puberty in 2 tropical breeds of beef cattle. Journal of Animal Science, 89 6: 1669-1683.

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Author Fortes, M. R. S.
Reverter, A.
Nagaraj, S. H.
Zhang, Y.
Jonsson, N. N.
Barris, W.
Lehnert, S.
Boe-Hansen, G. B.
Hawken, R. J.
Title A single nucleotide polymorphism-derived regulatory gene network underlying puberty in 2 tropical breeds of beef cattle
Journal name Journal of Animal Science  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2011-06
Sub-type Article
DOI 10.2527/jas.2010-3681
Volume number 89
Issue number 6
ISSN 0021-8812
1525-3163
Start page 1669
End page 1683
Total pages 15
Place of publication Savoy, IL, United States
Publisher American Society of Animal Science
Collection year 2012
Language eng
Formatted abstract Harsh tropical environments impose serious challenges on poorly adapted species. In beef cattle, tropical adaptation in the form of temperature and disease resistance, coupled with acclimatization to seasonal and limited forage, comes at a cost to production efficiency. Prominent among these costs is delayed onset of puberty, a challenging phenotype to manipulate through traditional breeding mechanisms. Recently, system biology approaches, including gene networks, have been applied to the genetic dissection of complex phenotypes. We aimed at developing and studying gene networks underlying cattle puberty. Our starting material comprises the association results of ~50,000 SNP on 22 traits, including age at puberty, and 2 cattle breed populations: Brahman (n = 843) and Tropical Composite (n = 866). We defined age at puberty as the age at first corpus luteum (AGECL). By capturing the genes harboring mutations minimally associated (P < 0.05) to AGECL or to a set of traits related with AGECL, we derived a gene network for each breed separately and a third network for the combined data set. At the intersection of the 3 networks, we identified candidate genes and pathways that were common to both breeds. Resulting from these analyses, we identified an enrichment of genes involved in axon guidance, cell adhesion, ErbB signaling, and glutamate activity, pathways that are known to affect pulsatile release of GnRH, which is necessary for the onset of puberty. Furthermore, we employed network connectivity and centrality parameters along with a regulatory impact factor metric to identify the key transcription factors (TF) responsible for the molecular regulation of puberty. As a novel finding, we report 5 TF (HIVEP3, TOX, EYA1, NCOA2, and ZFHX4) located in the network intersecting both breeds and interacting with other TF, forming a regulatory network that harmonizes with the recent literature of puberty. Finally, we support our network predictions with evidence derived from gene expression in hypothalamic tissue of adult cows.
Copyright © 2011 by the American Society of Animal Science
Keyword Bos indicus
Bos taurus
Gene network
Genome-wide association
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online Feb 25, 2011 under: A SNP-derived regulatory gene network underlying puberty in two tropical breeds of beef cattle

 
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Created: Tue, 19 Apr 2011, 11:00:45 EST by Annette Winter on behalf of School of Veterinary Science