No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women

Beesley, Jonathan, Johnatty, Sharon E., Chen, Xiaoqing, Spurdle, Amanda B., Peterlongo, Paolo, Barile, Monica, Pensotti, Valeria, Manoukian, Siranoush, Radice, Paolo, Australian Ovarian Cancer Study Group, Kathleen Cuningham Consortium for Research in Familial Breast Cancer and Chenevix-Trench, Georgia (2011) No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women. Breast Cancer Research and Treatment, 126 1: 235-239. doi:10.1007/s10549-010-1292-2

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Author Beesley, Jonathan
Johnatty, Sharon E.
Chen, Xiaoqing
Spurdle, Amanda B.
Peterlongo, Paolo
Barile, Monica
Pensotti, Valeria
Manoukian, Siranoush
Radice, Paolo
Australian Ovarian Cancer Study Group
Kathleen Cuningham Consortium for Research in Familial Breast Cancer
Chenevix-Trench, Georgia
Title No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women
Journal name Breast Cancer Research and Treatment   Check publisher's open access policy
ISSN 0167-6806
1573-7217
Publication date 2011-02
Year available 2010
Sub-type Article (original research)
DOI 10.1007/s10549-010-1292-2
Volume 126
Issue 1
Start page 235
End page 239
Total pages 5
Place of publication New York, U.S.A.
Publisher Springer New York
Collection year 2011
Language eng
Formatted abstract
ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorphism (SNP) encoding an amino acid change has recently been shown to determine whether cerumen (earwax) is wet or dry. We hypothesised that this ABCC11 SNP may be associated with breast cancer risk because an association has been reported between wet earwax and increased risk of breast cancer. We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk.
© 2010 Springer Science+Business Media, LLC.
Keyword ABCC11
Breast cancer
Polymorphism
Risk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 17 December 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Fri, 08 Apr 2011, 16:40:53 EST by Debbie Banks on behalf of School of Medicine