Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

Milne, Roger L., Gaudet, Mia M., Spurdle, Amanda B., Fasching, Peter A., Couch, Fergus J., Benitez, Javier, Arias Perez, Jose Ignacio, Zamora, M. Pilar, Malats, Nuria, dos Santos Silva, Isabel, Gibson, Lorna J., Fletcher, Olivia, Johnson, Nichola, Anton-Culver, Hoda, Ziogas, Argyrios, Figueroa, Jonine, Brinton, Louise, Sherman, Mark E., Lissowska, Jolanta, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Sigurdson, Alice J., Linet, Martha S., Schonfeld, Sara J., Freedman, D. Michal, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Auvinen, Paivi, Andrulis, Irene L., Glendon, Gord, Knight, Julia A., Weerasooriya, Nayana, Cox, Angela, Reed, Malcolm W. R., Cross, Simon S., Dunning, Alison M., Ahmed, Shahana, Shah, Mitul, Brauch, Hiltrud, Ko, Yon-Dschun, Bruning, Thomas, GENICA Network, Lambrechts, Diether, Reumers, Joke, Smeets, Ann, Wang-Gohrke, Shan, Hall, Per, Dzene, Kamila, Liu, Jianjun, Irwanto, Astrid K., Chenevix-Trench, Georgia, Holland, Helene, kConFab, AOCS, Giles, Graham G., Baglietto, Laura, Severi, Gianluca, Bojensen, Stig E., Nordestgaard, Borge G., Flyger, Henrik, John, Esther M., West, Dee W., Whittemore, Alice S., Vachon, Celine, Olson, Janet E., Fredericksen, Zachary, Kosel, Matthew, Hein, Rebecca, Vrieling, Alina, Flesch-Janys, Dieter, Heinz, Judith, Beckmann, Matthias W., Heusinger, Katharina, Ekici, Arif B., Haeberle, Lothar, Humphreys, Manjeet K., Morrison, Jonathan, Easton, Doug F., Pharoah, Paul D., Garcia-Closas, Montserrat, Goode, Ellen L., Chang-Claude, Jenny, Brown, Melissa, Cummings, Margaret and Lakhani, Sunil (2010) Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Research, 12 6: R110.1-R110.11. doi:10.1186/bcr2797

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Author Milne, Roger L.
Gaudet, Mia M.
Spurdle, Amanda B.
Fasching, Peter A.
Couch, Fergus J.
Benitez, Javier
Arias Perez, Jose Ignacio
Zamora, M. Pilar
Malats, Nuria
dos Santos Silva, Isabel
Gibson, Lorna J.
Fletcher, Olivia
Johnson, Nichola
Anton-Culver, Hoda
Ziogas, Argyrios
Figueroa, Jonine
Brinton, Louise
Sherman, Mark E.
Lissowska, Jolanta
Hopper, John L.
Dite, Gillian S.
Apicella, Carmel
Southey, Melissa C.
Sigurdson, Alice J.
Linet, Martha S.
Schonfeld, Sara J.
Freedman, D. Michal
Mannermaa, Arto
Kosma, Veli-Matti
Kataja, Vesa
Auvinen, Paivi
Andrulis, Irene L.
Glendon, Gord
Knight, Julia A.
Weerasooriya, Nayana
Cox, Angela
Reed, Malcolm W. R.
Cross, Simon S.
Dunning, Alison M.
Ahmed, Shahana
Shah, Mitul
Brauch, Hiltrud
Ko, Yon-Dschun
Bruning, Thomas
GENICA Network
Lambrechts, Diether
Reumers, Joke
Smeets, Ann
Wang-Gohrke, Shan
Hall, Per
Dzene, Kamila
Liu, Jianjun
Irwanto, Astrid K.
Chenevix-Trench, Georgia
Holland, Helene
kConFab
AOCS
Giles, Graham G.
Baglietto, Laura
Severi, Gianluca
Bojensen, Stig E.
Nordestgaard, Borge G.
Flyger, Henrik
John, Esther M.
West, Dee W.
Whittemore, Alice S.
Vachon, Celine
Olson, Janet E.
Fredericksen, Zachary
Kosel, Matthew
Hein, Rebecca
Vrieling, Alina
Flesch-Janys, Dieter
Heinz, Judith
Beckmann, Matthias W.
Heusinger, Katharina
Ekici, Arif B.
Haeberle, Lothar
Humphreys, Manjeet K.
Morrison, Jonathan
Easton, Doug F.
Pharoah, Paul D.
Garcia-Closas, Montserrat
Goode, Ellen L.
Chang-Claude, Jenny
Brown, Melissa
Cummings, Margaret
Lakhani, Sunil
Title Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
Journal name Breast Cancer Research   Check publisher's open access policy
ISSN 1465-5411
1465-542X
Publication date 2010
Sub-type Article (original research)
DOI 10.1186/bcr2797
Open Access Status DOI
Volume 12
Issue 6
Start page R110.1
End page R110.11
Total pages 11
Place of publication London, United Kingdom
Publisher Current Medicine Group
Collection year 2011
Language eng
Formatted abstract
Introduction: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine how these variants combine with a subset of other known risk factors to influence breast cancer risk in white women of European ancestry using case-control studies participating in the Breast Cancer Association Consortium.

Methods: We evaluated two-way interactions between each of age at menarche, ever having had a live birth, number of live births, age at first birth and body mass index (BMI) and each of 12 single nucleotide polymorphisms (SNPs) (10q26-rs2981582 [FGFR2], 8q24-rs13281615, 11p15-rs3817198 [LSP1], 5q11-rs889312 [MAP3K1], 16q12-rs3803662 [TOX3], 2q35-rs13387042, 5p12-rs10941679 [MRPS30], 17q23-rs6504950 [COX11], 3p24-rs4973768 [SLC4A7], CASP8-rs17468277, TGFB1-rs1982073 and ESR1-rs3020314). Interactions were tested for by fitting logistic regression models including per-allele and linear trend main effects for SNPs and risk factors, respectively, and single-parameter interaction terms for linear departure from independent multiplicative effects.

Results: These analyses were applied to data for up to 26,349 invasive breast cancer cases and up to 32,208 controls from 21 case-control studies. No statistical evidence of interaction was observed beyond that expected by chance. Analyses were repeated using data from 11 population-based studies, and results were very similar.

Conclusions: The relative risks for breast cancer associated with the common susceptibility variants identified to date do not appear to vary across women with different reproductive histories or body mass index (BMI). The assumption of multiplicative combined effects for these established genetic and other risk factors in risk prediction models appears justified.


Keyword Single-nucleotide polymorphisms
Confer susceptibility
Family registry
Brca1
Chek2-asterisk-1100delc
Ovarian-cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 08 Apr 2011, 15:57:41 EST by Debbie Banks on behalf of School of Medicine