Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists

Black, Matthew, Trent, Amanda, Tirrell, Matthew and Olive, Colleen (2010) Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists. Expert Review of Vaccines, 9 2: 157-173. doi:10.1586/ERV.09.160


Author Black, Matthew
Trent, Amanda
Tirrell, Matthew
Olive, Colleen
Title Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists
Journal name Expert Review of Vaccines   Check publisher's open access policy
ISSN 1476-0584
1744-8395
Publication date 2010-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/ERV.09.160
Volume 9
Issue 2
Start page 157
End page 173
Total pages 17
Editor Adam Williams
Place of publication London, United Kingdom
Publisher Expert Reviews
Collection year 2011
Language eng
Formatted abstract
Considerable success has been made with many peptide antigen formulations, and peptide-based vaccines are emerging as the next generation of prophylactic and remedial immunotherapy. However, finding an optimal platform balancing all of the requirements for an effective, specific and safe immune response remains a major challenge for many infectious and chronic diseases. This review outlines how peptide immunogenicity is influenced by the way in which peptides are presented to the immune system, underscoring the need for multifunctional delivery systems that couple antigen and adjuvant into a single construct. Particular attention is given to the ability of Toll-like receptor agonists to act as adjuvants. A survey of recent approaches to developing peptide antigen delivery systems is given, many of which incorporate Toll-like receptor agonists into the design.
Keyword Antigen delivery system
Liposome
Micelle
Nanoparticle
Peptide
Subunit vaccine
Toll-like receptor
Virus-like particle
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Public Health Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 61 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 04 Apr 2011, 22:27:55 EST by Debbie Banks on behalf of !NON-HERDC