'Click peptide': A novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues

Sohma, Youhei, Taniguchi, Atsuhiko, Yoshiya, Taku, Chiyomori, Yousuke, Fukao, Fukue, Nakamura, Setsuko, Skwarczynski, Mariusz, Okada, Takuma, Ikeda, Keisuke, Hayashi, Yoshio, Kimura, Tooru, Hirota, Shun, Matsuzaki, Katsumi and Kiso, Yoshiaki (2006) 'Click peptide': A novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues. Journal of Peptide Science, 12 12: 823-828. doi:10.1002/psc.817


Author Sohma, Youhei
Taniguchi, Atsuhiko
Yoshiya, Taku
Chiyomori, Yousuke
Fukao, Fukue
Nakamura, Setsuko
Skwarczynski, Mariusz
Okada, Takuma
Ikeda, Keisuke
Hayashi, Yoshio
Kimura, Tooru
Hirota, Shun
Matsuzaki, Katsumi
Kiso, Yoshiaki
Title 'Click peptide': A novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues
Formatted title
'Click peptide': A novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid β peptide analogues
Journal name Journal of Peptide Science   Check publisher's open access policy
ISSN 1075-2617
1099-1387
Publication date 2006-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/psc.817
Volume 12
Issue 12
Start page 823
End page 828
Total pages 6
Editor Ettore Benedetti
Place of publication Bognor Regis, West Sussex, U.K.
Publisher John Wiley & Sons
Language eng
Formatted abstract
After over a decade of studies on aspartic protease inhibitors and water-soluble prodrugs, we have been developing a novel method, since 2003, called 'O-acyl isopeptide method', for the synthesis of peptides containing difficult sequences. With our recent discoveries of 'O-acyl isodipeptide unit' and the 'racemization-free segment condensation method', this method has further evolved as a general synthetic method for peptides. Moreover, 'Click Peptide', which could be a powerful tool for identifying the pathological functions of amyloid β peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology-oriented research.
Keyword Alzheimer's disease
Amyloid β peptide
Difficult sequence
O-acyl isopeptide method
Amyloid beta peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special Issue: 10th Naples Workshop on Bioactive Peptides

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Sun, 03 Apr 2011, 13:17:16 EST by Dr Mariusz Skwarczynski on behalf of School of Chemistry & Molecular Biosciences