The potential role of hepatic stellate cells in iron homeostasis

Ruddell, R. G., Darshan, D., Hoang-Le, D., Anderson, G. J. and Ramm, G. A. (2010). The potential role of hepatic stellate cells in iron homeostasis. In: Abstracts of: Australian Gastroenterology Week 2010. AGW2010: Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, (A4-A4). 20-23 October 2010. doi:10.1111/j.1440-1746.2010.06450.x

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Author Ruddell, R. G.
Darshan, D.
Hoang-Le, D.
Anderson, G. J.
Ramm, G. A.
Title of paper The potential role of hepatic stellate cells in iron homeostasis
Conference name AGW2010: Australian Gastroenterology Week 2010
Conference location Gold Coast, QLD, Australia
Conference dates 20-23 October 2010
Proceedings title Abstracts of: Australian Gastroenterology Week 2010   Check publisher's open access policy
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
Place of Publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Publication Year 2010
Sub-type Published abstract
DOI 10.1111/j.1440-1746.2010.06450.x
ISSN 0815-9319
Volume 25
Issue Supp. s3
Start page A4
End page A4
Total pages 1
Collection year 2011
Language eng
Formatted Abstract/Summary
Introduction: Iron homeostasis requires strict regulation of dietary iron intake as the human body lacks a dedicated iron excretory pathway. Iron uptake from the gut is under the control of the liver-derived peptide hepcidin. Hepcidin in turn is believed to be regulated by levels of diferric (holo) transferrin and bone morphogenetic protein-6 (BMP6). Within the liver hepatic stellate cells (HSC) are the principle source of BMP6, suggesting they may play a regulatory role in iron homeostasis.

Conclusions: HSC express a range of genes that are vital in the maintenance of iron homeostasis. Neither BMP6 nor hepcidin expression could be modulated directly by altering HSC iron status, but changes in expression in response to serum from rats undergoing erythropoiesis, suggest that HSC may play an important role in regulating iron homeostasis.
© 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Special Issue: Australian Gastroenterology Week 2010. Published under "Basic Science".

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Created: Thu, 31 Mar 2011, 15:01:06 EST by Debbie Banks on behalf of !NON-HERDC