Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: The role of inflammation in a noninflammatory liver disease

Ramm, Grant A. and Ruddell, Richard G. (2010) Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: The role of inflammation in a noninflammatory liver disease. Seminars in Liver Disease, 30 3: 271-287. doi:10.1055/s-0030-1255356

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Author Ramm, Grant A.
Ruddell, Richard G.
Title Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: The role of inflammation in a noninflammatory liver disease
Journal name Seminars in Liver Disease   Check publisher's open access policy
ISSN 0272-8087
Publication date 2010-08-01
Sub-type Article (original research)
DOI 10.1055/s-0030-1255356
Volume 30
Issue 3
Start page 271
End page 287
Total pages 17
Place of publication United States
Publisher Thieme Medical Publishers
Collection year 2011
Language eng
Abstract Iron is a crucially important element in normal cellular function and thus the regulation of iron homeostasis is tightly controlled. When this regulation is disrupted, for instance in hereditary hemochromatosis, abnormal intestinal absorption of iron leads to cellular toxicity, tissue injury, and organ fibrosis via the deposition of this iron in parenchymal cells of a number of different organs such as the heart, pancreas, and liver. Iron-generated oxyradicals contribute to the peroxidation of lipid membranes leading to organelle fragility and cellular toxicity. This process is thought to contribute to hepatocellular necrosis and/or apoptosis in the liver with the subsequent activation of hepatic stellate cells and the development of hepatic fibrosis and cirrhosis. Understanding the processes associated with normal iron homeostasis is crucially important as this will ultimately provide clues as to how altered iron uptake and delivery leads to tissue injury and organ dysfunction in diseases of disordered iron metabolism. This review highlights recent advances in identifying major regulators associated with hepatic iron homeostasis and examines the potential mechanisms involved in the development of iron overload-induced hepatic injury and fibrogenesis. Copyright © 2010 by Thieme Medical Publishers, Inc.
Keyword Hemochromatosis
Hepatic fibrosis
Hepatic stellate cell
Hepcidin
Inflammation
Iron
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Thu, 31 Mar 2011, 01:55:24 EST by Debbie Banks on behalf of School of Medicine