Posttraumatic epilepsy

Kharatishvili, Irina and Pitkänen, Asla (2010) Posttraumatic epilepsy. Current Opinion in Neurology, 23 2: 183-188. doi:10.1097/WCO.0b013e32833749e4


Author Kharatishvili, Irina
Pitkänen, Asla
Title Posttraumatic epilepsy
Journal name Current Opinion in Neurology   Check publisher's open access policy
ISSN 1350-7540
1473-6551
Publication date 2010-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/WCO.0b013e32833749e4
Volume 23
Issue 2
Start page 183
End page 188
Total pages 6
Editor Michael Sperling
Richard S. J. Frackowiak
Place of publication Philadelphia, PA, U.S.A.
Publisher Lippincott Williams & Wilkins
Collection year 2011
Language eng
Formatted abstract
Purpose of review: The purpose of this study is to focus on recent advances in understanding of the genetic and epidemiologic risk factors, development, modeling, and prevention of epilepsy after traumatic brain injury (TBI).
Recent findings: Epidemiologic data suggest that the epileptogenic period after TBI in humans may last longer than previously thought. Depression was found to be an important risk factor for posttraumatic epilepsy (PTE). Once PTE has developed, it remits less often than previously reported. Moreover, patients with PTE appear to have a higher mortality rate than patients with TBI without epilepsy. In animal models it was reported that in addition to rats, also mice develop PTE. Furthermore, the immature rat brain is sensitive to TBI-induced epileptogenesis. The development of a lowered seizure threshold after TBI can be alleviated by pharmacotherapy in rats.
Summary: These observations provide small but encouraging steps towards a better understanding of the mechanisms of posttraumatic epileptogenesis, which is a key to developing a cure for this condition.
© 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins
Keyword Animal models
Early seizures
Epilepsy
Prevention
Risk factors
Traumatic brain injury
Unprovoked seizures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Non HERDC
Centre for Advanced Imaging Publications
 
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Created: Wed, 30 Mar 2011, 12:30:40 EST by Sandrine Ducrot on behalf of !NON-HERDC