Dyslexia and DYX1C1: Deficits in reading and spelling associated with a missense mutation

Bates, T. C., Lind, P.A., Luciano, M., Montgomery, G. W., Martin, N. G. and Wright, M. J. (2010) Dyslexia and DYX1C1: Deficits in reading and spelling associated with a missense mutation. Molecular Psychiatry, 15 12: 1190-1196. doi:10.1038/mp.2009.120

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ239425_authaffil_staffdata_Martin.pdf HERDC evidence - not publicly available application/pdf 491.94KB 1

Author Bates, T. C.
Lind, P.A.
Luciano, M.
Montgomery, G. W.
Martin, N. G.
Wright, M. J.
Title Dyslexia and DYX1C1: Deficits in reading and spelling associated with a missense mutation
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1038/mp.2009.120
Volume 15
Issue 12
Start page 1190
End page 1196
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
The status of DYX1C1 (C15q21.3) as a susceptibility gene for dyslexia is unclear. We report the association of this gene with reading and spelling ability in a sample of adolescent twins and their siblings. Family-based association analyses were carried out on 13 single-nucleotide polymorphisms (SNPs) in DYX1C1, typed in 790 families with up to 5 offspring and tested on 6 validated measures of lexical processing (irregular word) and grapheme-phoneme decoding (pseudo-word) reading- and spelling-based measures of dyslexia, as well as a short-term memory measure. Significant association was observed at the misssense mutation rs17819126 for all reading measures and for spelling of lexical processing words, and at rs3743204 for both irregular and nonword reading. Verbal short-term memory was associated with rs685935. Support for association was not found at rs3743205 and rs61761345 as previously reported by Taipale et al., but these SNPs had very low (0.002 for rs3743205) minor allele frequencies in this sample. These results suggest that DYX1C1 influences reading and spelling ability with additional effects on short-term information storage or rehearsal. Missense mutation rs17819126 is a potential functional basis for the association of DYX1C1 with dyslexia. © 2010 Macmillan Publishers Limited All rights reserved.
Keyword Dyslexia
Reading ability
Spelling ability
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 38 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 29 Mar 2011, 14:02:08 EST by Debbie Banks on behalf of School of Medicine