Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The Australian twins eye study

Sun, Cong, Ponsonby, Anne-Louise, Brown, Shayne A., Kearns, Lisa S., Mackinnon, Jane R., Barbour, Julie M., Ruddle, Jonathan B., Wright, Margaret J., Martin, Nicholas G., Dwyer, Terence and Mackey, David A. (2010) Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The Australian twins eye study. American Journal of Ophthalmology, 150 6: 909-916. doi:10.1016/j.ajo.2010.06.028

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Author Sun, Cong
Ponsonby, Anne-Louise
Brown, Shayne A.
Kearns, Lisa S.
Mackinnon, Jane R.
Barbour, Julie M.
Ruddle, Jonathan B.
Wright, Margaret J.
Martin, Nicholas G.
Dwyer, Terence
Mackey, David A.
Title Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The Australian twins eye study
Journal name American Journal of Ophthalmology   Check publisher's open access policy
ISSN 0002-9394
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1016/j.ajo.2010.06.028
Volume 150
Issue 6
Start page 909
End page 916
Total pages 8
Place of publication Philadelphia, PA, U.S.A.
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
To examine the relationship of birth weight with ocular measures in a Caucasian twin population.

Cross-sectional study of 1498 twins (308 monozygotic and 441 dizygotic pairs) aged between 5 to 80 years participating in the Australian Twins Eye Study.


All participants underwent ophthalmic examination including bilateral cycloplegic autorefraction, keratometry, interpupillary distance (IPD), central corneal thickness, intraocular pressure (IOP), and retinal photography. Birth weight and gestation were obtained from a self-administered questionnaire. A subset of the twins also participated in the Tasmanian Infant Health Study (288) and the Childhood Blood Pressure Study (184), which collected data on birth parameters allowing for verification of data. Linear mixed models were used for the main analysis.

Both the within-pair (βw 0.27, 95% confidence interval [CI] 0.15, 0.38 mm per kg increase in birth weight, P < .001) and between-pair associations (βB 0.22, 95% CI 0.08, 0.35, P = .002) of birth weight with axial length were significant and of similar magnitude (difference in effect, P = .56), after adjusting for relevant confounders. In contrast, birth weight was negatively associated with corneal curvature (βw −0.82, 95% CI −1.09, −0.55 diopters per kg increase; βB −0.69, 95% CI −0.98, −0.41, both P < .001). These associations remained significant within dizygotic and monozygotic pairs. Refraction, anterior chamber depth, IPD, IOP, and optic disc parameters are unrelated to birth weight.

Consistent with previous studies in singleton children, lower birth weight is associated with shorter axial length and more curved corneas in this twin study. This also adds new insights into the emmetropization process.
Copyright © 2010 Elsevier Inc. All rights reserved.
Keyword Optic-nerve head
Fetal origins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 29 Mar 2011, 13:50:27 EST by Debbie Banks on behalf of School of Medicine