Major depression and the metabolic syndrome

Foley, Debra L., Morley, Katherine I., Madden, Pamela A. F., Heath, Andrew C., Whitfield, John B. and Martin, Nicholas G. (2010) Major depression and the metabolic syndrome. Twin Research and Human Genetics, 13 4: 347-358. doi:10.1375/twin.13.4.347

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Author Foley, Debra L.
Morley, Katherine I.
Madden, Pamela A. F.
Heath, Andrew C.
Whitfield, John B.
Martin, Nicholas G.
Title Major depression and the metabolic syndrome
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1375/twin.13.4.347
Volume 13
Issue 4
Start page 347
End page 358
Total pages 12
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2011
Language eng
Abstract The aim of this study is to characterize the relationship between major depression and the metabolic syndrome in a large community based sample of Australian men and women aged 26-90 years. A lifetime history of major depression was assessed by telephone interview following the DSM-III-R. A current history of metabolic syndrome was assessed following the United States National Cholesterol Education Program Adult Treatment Panel III (NCEP AP-III) guidelines 1 to 3 years later. Logistic regression was used to estimate the association between depression and the metabolic syndrome, and its component criteria, controlling for age, sex and alcohol dependence. There was no association between a lifetime history of major depression and the presence of the metabolic syndrome. There was a weak association between depression and low high-density lipoprotein cholesterol but not with other component criteria of the metabolic syndrome. Despite calls for interventions directed at depression to reduce the onset of the metabolic syndrome there are important failures to replicate in large samples such as this, no consensus regarding the threshold at which depression may pose a significant risk even allowing for heterogeneity across populations, and no consensus regarding confounders that may explain inter-study differences. The absence of any dosage effect of depression on the associated risk for the metabolic syndrome in other unselected samples does not support a direct causal relationship. The call for intervention studies on the basis of the currently published evidence base is unwarranted.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Tue, 29 Mar 2011, 13:05:36 EST by Debbie Banks on behalf of School of Medicine