Replacement of the corneal endothelium and the conceptual framework for an artificial substitute

Chirila, Traian V., Madden, Peter W. and Hirst, Lawrie W. (2010) Replacement of the corneal endothelium and the conceptual framework for an artificial substitute. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 5 1: 13-29. doi:10.4028/www.scientific.net/JBBTE.5.13


Author Chirila, Traian V.
Madden, Peter W.
Hirst, Lawrie W.
Title Replacement of the corneal endothelium and the conceptual framework for an artificial substitute
Journal name Journal of Biomimetics, Biomaterials, and Tissue Engineering   Check publisher's open access policy
ISSN 1662-1018
1662-100X
ISBN 9780000000422
0000000426
Publication date 2010-02
Sub-type Article (original research)
DOI 10.4028/www.scientific.net/JBBTE.5.13
Volume 5
Issue 1
Start page 13
End page 29
Total pages 17
Editor A.J. Ruys
Place of publication Stafa-Zurich, Switzerland
Publisher Trans Tech Publications
Collection year 2011
Language eng
Formatted abstract
Dysfunction of the corneal endothelium due to cell loss caused by aging, disease or trauma can lead to severe visual impairment and blindness. Traditionally, dysfunctional endothelia are managed surgically, by removing the entire central cornea and transplanting either donor corneal tissue (penetrating keratoplasty), or just endothelia isolated from donor corneas. As in many cases it is only the corneal endothelium requiring replacement, many attempts were made over the last decades to develop an endothelial substitute, thereby precluding the need for the use of full donor corneas. This article reviews these attempts, which include artificial membranes, cell-coated corneal transplants, and cell-coated membranes. The presumption of an artificial corneal endothelium capable of duplicating the transendothelial ion-and-fluid transport function is examined in light of the latest hypotheses regarding the mechanism of this function.
© (2010) Trans Tech Publications, Switzerland
Keyword Corneal endothelium
Penetrating keratoplasty
Cell-based reconstructs
Transepithelial transport
Corneal endothelial pump
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Tue, 29 Mar 2011, 09:11:25 EST by Debbie Banks on behalf of School of Medicine