Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat — 11 months follow-up

Immonen, Riikka J., Kharatishvili, Irina, Niskanen, Juha-Pekka, Gröhn, Heidi, Pitkänen, Asla and Gröhn, Olli H. J. (2009) Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat — 11 months follow-up. Experimental Neurology, 215 1: 29-40. doi:10.1016/j.expneurol.2008.09.009

Author Immonen, Riikka J.
Kharatishvili, Irina
Niskanen, Juha-Pekka
Gröhn, Heidi
Pitkänen, Asla
Gröhn, Olli H. J.
Title Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat — 11 months follow-up
Journal name Experimental Neurology   Check publisher's open access policy
ISSN 0014-4886
Publication date 2009-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.expneurol.2008.09.009
Volume 215
Issue 1
Start page 29
End page 40
Total pages 12
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
To understand the dynamics of progressive brain damage after lateral fluid-percussion induced traumatic brain injury (TBI) in rat, which is the most widely used animal model of closed head TBI in humans, MRI follow-up of 11 months was performed. The evolution of tissue damage was quantified using MRI contrast parameters T2, T, diffusion (Dav), and tissue atrophy in the focal cortical lesion and adjacent areas: the perifocal and contralateral cortex, and the ipsilateral and contralateral hippocampus. In the primary cortical lesion area, which undergoes remarkable irreversible pathologic changes, MRI alterations start at 3 h post-injury and continue to progress for up to 6 months. In more mildly affected perifocal and hippocampal regions, the robust alterations in T2, T, and Dav at 3 h to 3 d post-injury normalize within the next 9-23 d, and thereafter, progressively increase for several weeks. The severity of damage in the perifocal and hippocampal areas 23 d post-injury appeared independent of the focal lesion volume. Magnetic resonance spectroscopy (MRS) performed at 5 and 10 months post-injury detected metabolic alterations in the ipsilateral hippocampus, suggesting ongoing neurodegeneration and inflammation. Our data show that TBI induced by lateral fluid-percussion injury triggers long-lasting alterations with region-dependent temporal profiles. Importantly, the temporal pattern in MRI parameters during the first 23 d post-injury can indicate the regions that will develop secondary damage. This information is valuable for targeting and timing interventions in studies aiming at alleviating or reversing the molecular and/or cellular cascades causing the delayed injury.
© 2008 Elsevier Inc. All rights reserved.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Available online 27 September 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 28 Mar 2011, 16:29:46 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging